منابع مشابه
Tumor Suppressing Pathways
The search for the tumor suppressor gene on 18q Identification of the cell regulatory genes that drive carexemplifies this challenge. The initial candidate gene cinogenesis is one of the major goals in cancer research, identified in the 18q region, DCC, seemed at first to resulting in new anticancer drug targets and new therameet the appropriate criteria for a tumor suppressor peutic and diagno...
متن کاملTumor-suppressing 15-Lipoxygenase-2
Lipoxygenases (LOX) comprise a family of non-heme-iron-containing proteins that cata-lyze the dioxygenation of polyunsaturated fatty acids to form bioactive lipids. Metabolism of arachidonic acid by LOXs leads to the formation of regioisomeric cis/trans-conjugated hydroxyeicosatetraenoic acids (HeTes), leukot-rienes, lipoxins, and hepoxilins. Dependent on the predominant position of the incorpo...
متن کاملCrosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways
Mitochondrial-nucleus cross talks and mitochondrial retrograde regulation can play a significant role in cellular properties. Transmitochondrial cybrid systems (cybrids) are an excellent tool to study specific effects of altered mitochondria under a defined nuclear background. The majority of the studies using the cybrid model focused on the significance of specific mitochondrial DNA variations...
متن کاملEF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma
A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investigated. The aim of our study was to evaluate the molecular mechanisms underlying...
متن کاملGenistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells
BACKGROUND Genistein (Gen) exhibits anti-mutagenic and anti-metastatic activities in hepatoma cell lines. Gen has suppressive effects on tumor growth and angiogenesis in nude mice. Gen suppresses the enzymatic activity of matrix metalloproteinase (MMP)-9; however, the mechanism underlying its anti-invasive activity on hepatocellular carcinoma (HCC) cells is unclear. METHODS In this study, the...
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ژورنال
عنوان ژورنال: Cell
سال: 1998
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81124-1